In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole

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In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole.

OBJECTIVES MUC7 12-mer (RKSYKCLHKRCR), a cationic peptide derived from human salivary MUC7 mucin, exhibits potent in vitro antifungal activity, as determined by killing assays in phosphate buffer. In this study we examined the MUC7 12-mer antifungal activity alone or in combination with other antifungal agents in LYM medium (modified RPMI 1640). METHODS Antifungal activities of MUC7 12-mer an...

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Human salivary mucin MUC7 12-mer-L and 12-mer-D peptides: antifungal activity in saliva, enhancement of activity with protease inhibitor cocktail or EDTA, and cytotoxicity to human cells.

MUC7 12-mer-L exhibits potent in vitro antifungal activity in low-ionic-strength buffers. In this study, we investigated the anticandidal activity and stability of MUC7 12-mer-L and its all-D-amino-acid isomer, along with Hsn5 12-mer (P113) and magainin-II, in human clarified and unclarified saliva in the absence or presence of protease inhibitor cocktail (PIC, which includes EDTA) or EDTA alon...

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Completely encapsulated oligothiophenes up to 12-mer.

A series of oligothiophenes covered with tert-butyldiphenylsilyl (TBDPS) groups was synthesized, and the spectroscopic measurements and X-ray analyses revealed that the oligothiophene backbone is completely encapsulated by bulky TBDPS groups.

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MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action.

This study was aimed at examining the spectrum of antimicrobial activity of MUC7 20-mer (N-LAHQKPFIRKSYKCLHKRCR-C; residues 32 to 51 of MUC7, the low-molecular-weight human salivary mucin, comprised of 357 residues) and comparing its antifungal properties to those of salivary histatin 5 (Hsn-5). We also examined the secondary structure of the 20-mer and the possible mechanism of its antifungal ...

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Discovery of 12-mer peptides that bind to wood lignin.

Lignin, an abundant terrestrial polymer, is the only large-volume renewable feedstock composed of an aromatic skeleton. Lignin has been used mostly as an energy source during paper production; however, recent interest in replacing fossil fuels with renewable resources has highlighted its potential value in providing aromatic chemicals. Highly selective degradation of lignin is pivotal for indus...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2004

ISSN: 1460-2091

DOI: 10.1093/jac/dkh181